Leading a Revolution in Health

Mike Bonney is Executive Chairman of Kaleido. A veteran of the biopharmaceutical industry, he initially served as Kaleido’s CEO until August 2018. Previously, Bonney was CEO and Director of Cubist Pharmaceuticals from 2003 until 2014. Under his leadership, Cubist grew from a struggling micro-cap to the world’s leading antibiotic company, and was acquired by Merck early in 2015 for $9.5 billion. Prior to Cubist, Bonney was Vice President of Sales and Marketing at Biogen where he built the company’s commercial infrastructure for the launch of its first product. Before joining Biogen, he spent 11 years at Zeneca Pharmaceuticals in a range of commercial, operating and strategic roles, ending his career there as National Business Director. Bonney also chairs the boards of Alnylam Pharmaceuticals, Magenta Therapeutics and Bates College. He is a member of a number of other boards, including Celgene Corporation, Syros Pharmaceuticals and Sarepta Therapeutics. Bonney was a regional winner and national finalist (2013) in the life science segment of Ernst & Young’s Entrepreneur of the Year and was one of six executives nationwide named as Marketwatch’s CEO of the Year (2011). He received his undergraduate degree in economics from Bates College.

Alison Lawton has more than 30 years of experience in a range of executive and operating roles in the biopharmaceutical industry. She became CEO and a member of Kaleido’s Board of Directors in August 2018 after initially joining the Company in December 2017 as President & Chief Operating Officer. Prior to Kaleido, Ms. Lawton was COO at Aura Biosciences, and she previously held the same role at OvaScience in 2013. She spent more than 20 years at Genzyme Corporation and at Genzyme Sanofi. She served as Senior Vice President and General Manager of Sanofi (Genzyme) Biosurgery, where she was responsible for the surgical, cell therapy and regenerative medicine, and orthopedics franchises. Earlier, as SVP of Global Market Access for Genzyme, Ms. Lawton was involved in leading global functional organizations, including regulatory affairs and quality systems, public policy, health outcomes and strategic pricing, product safety and risk management. Additionally, Ms. Lawton worked for seven years in the U.K. at Warner-Lambert/Parke-Davis. She previously served two terms as the industry representative on the Food & Drug Administration’s Cell & Gene Therapy Advisory Committee and as Chairman of the Board of the Regulatory Affairs Professional Society (RAPS). She is currently an independent Director of ProQR Therapeutics and Verastem, Inc., and was previously a director on the boards of Cubist Pharmaceuticals, CoLucid Pharmaceuticals, and Magenta Therapeutics. She earned her Bachelor of Science degree in Pharmacology from King’s College London.

Geoffrey von Maltzahn is a leading innovator and entrepreneur in the microbiome and biotechnology and is a co-founder of companies that have achieved over $3 billion in private and public market capitalization. He is a partner at Flagship Pioneering and has co-founded multiple biotech companies including Seres Therapeutics (NASDAQ: MCRB), Indigo Agriculture, Axcella Health, and Sienna Biopharmaceuticals (NASDAQ: SNNA). He recently served as the President of Indigo, where he led the creation of the world’s largest plant microbiome database and development of the company’s first commercial products. Von Maltzahn is an inventor on more than 100 patents and patent applications in biotech, nutrition and microbiome-based technologies and has been recognized with numerous awards, including the prestigious Lemelson-MIT student prize, given to the most innovative student at MIT. Von Maltzahn’s innovations have been profiled by the Economist, CNN, Fortune, Scientific American, Popular Science and others. He received his PhD from MIT in the Harvard-MIT Division of Health Sciences and Technology.

Joshua Brumm has more than a decade of operations, finance and investment banking experience in the life science industry. Prior to joining Kaleido in April 2018, Mr. Brumm was COO and CFO at Versartis, where he oversaw the company’s financial strategy, including the successful completion of a $145 million initial public offering, played an integral role in product strategy, and helped negotiate the company’s first product partnership. Prior to that, he was executive vice president of finance and principal financial officer at Pharmacyclics, and CFO at ZELTIQ Aesthetics, where he also served in corporate development and sales roles. He also was director of finance at Proteolix, Inc., helping in the sale of the company to Onyx Pharmaceuticals. Over the course of his career, Mr. Brumm has raised more than $800 million in equity financings. In 2014, he was named Silicon Valley Business Journal’s CFO of the Year for companies under $500 million. He also held investment banking roles at Citigroup Global Markets, Inc. and Morgan Stanley. He holds a B.A. in Business Administration from the University of Notre Dame.

Dr. Miller oversees the consumer product research and development pipeline at Kaleido, following a successful 30 year career at Abbott Nutrition. Miller was responsible for global pediatric, adult, and performance nutrition product development, innovation, new ventures, medical safety, clinical and preclinical research as the Divisional Vice President of R&D, Scientific and Medical Affairs at Abbott Nutrition, and was part of the Executive team managing the $7 billion nutrition business. He was an architect of the global expansion of Abbott Nutrition, establishing R&D Centers in Singapore, Shanghai, China and Bangalore, India. Dr. Miller was co-chair of the Abbott Scientific Governing Board from 2013-2016, overseeing talent development and program efforts of Abbott’s 2,500 scientists for all Abbott Laboratories divisions. He continues to develop leadership potential in scientists through his responsibilities as a Commissioner for the Food Systems Leadership Institute part of the Association of Public and Land Grant Universities. Miller holds a Ph.D. in Nutritional Biochemistry from the University of Wisconsin-Madison, and completed a Staff fellowship at the National Institute of Health.

John W. Davies, Ph.D. will oversee the research and technology platform for Kaleido. John has more than 25 years of experience creating and leading diverse technology teams. He received his Ph.D. in synthetic organic chemistry from University College London, before embarking on postdoctoral studies in the emerging field of computational modeling at GlaxoSmithKline. In 1992, Dr. Davies joined Sandoz in London to carry out computational research in neuroscience, before moving to the United States where he supported a broad range of therapeutic disease areas. John held increasing responsibility for technology disciplines and, at Novartis, was responsible for early discovery informatics, sample management, robotics and automation. During this time, he spearheaded the installation of the new automation platform for high-throughput screening (HTS) and initiated the development of a new $25 million sample management environment in Cambridge. Computationally, he led an initiative that reshaped the data and computational strategy for the Novartis Institutes for BioMedical Research (NIBR) and developed a number of unique industry-leading computational approaches, which resulted in more than 100 publications across the informatics group.

Michael Bruce brings more than 20 years of pharmaceutical and biotech product development experience to Kaleido. Michael was one of the earliest hires at CRISPR Therapeutics, where he built the project, portfolio and alliance management functions, including the buildup and successful launch of alliances with Vertex and Bayer. Michael also worked on product development at Millennium Pharmaceuticals, and joined Wyeth, where he led oncology drug development projects. He was a contributing leader to the successful development of five globally marketed drug products. Michael also led project and portfolio management functions at Pfizer, ultimately leading the project management group and governance bodies for the Phase 0-2 portfolio. He has a B.A. from Williams College and a Ph.D. from Stanford University.

Ms. Arnold brings more than 20 years of experience in human resources to Kaleido, including extensive work in the biopharmaceutical industry. Prior to joining Kaleido, Ms. Arnold was head of the HR business partnership function at Moderna Therapeutics, and helped lead the HR organization during a period of significant growth, including implementing talent and engagement initiatives, compensation framework and benefits program enhancements. Prior to that, she was at Celgene Avilomics Research (formerly Avila Therapeutics) where she was responsible for building and developing the HR infrastructure for the company’s early research and development division. She also held senior HR positions at Inotek Pharmaceuticals and Amylin Pharmaceuticals. Ms. Arnold received her Bachelor of Science degree from Colorado State University.

Ms. Stewart has worked for more than 25 years in biopharmaceutical regulatory affairs, with significant experience devising innovative strategies for novel therapeutics, overseeing regulatory submissions at various stages of product development and leading interactions with global health authorities. Previously, in addition to being an independent regulatory consultant for several years, she was senior vice president of regulatory affairs, quality, and compliance at Tokai Pharmaceuticals and vice president, regulatory affairs at Transmolecular. She also spent more than 10 years at Genzyme Corporation in regulatory and compliance roles, including serving as vice president, regulatory affairs. She received her J.D. from Concord Law School at Purdue University Global and her B.A. from the University of Massachusetts.

Dr. Sofen brings to Kaleido extensive experience in technical innovation, product development and manufacturing, including more than 15 years in the biotechnology industry. Most recently, he was a vice president of technical operations at CRISPR Therapeutics, where he built and led the company’s process development, analytical sciences and manufacturing capabilities. Dr. Sofen also held senior technology and operations positions at Biogen, Genzyme Corporation and the Novartis-MIT Center for Continuous Manufacturing. He received his Ph.D. in bioinorganic chemistry from University of California, Berkley and his B.A. from Reed College.

Jeff Moore brings more than 20 years of financial and operations experience in life science technology and Big 4 accounting to Kaleido. Prior to joining Kaleido, he was SVP, Finance and Operations for Axcella Health. In addition, Moore has gained a wealth of experience building rapidly emerging life science companies serving as Chief Financial Officer or in other senior financial and operational roles for number of companies including Helicos BioSciences (NASDAQ: HLCS), Joule Unlimited, BG Medicine (NASDAQ: BGMD), Affinnova, Inc., and Flagship Ventures. Prior to joining Flagship Ventures, Moore served as the Director of Business Analysis and Planning at Celera Genomics, the first biotechnology firm to sequence the human genome, and as Vice President, Treasury Operations and Chief Accounting Officer at PerSeptive Biosystems (NASDAQ: PBIO). Moore started his career with Price Waterhouse in its Emerging Growth Company practice providing audit and advisory services to both private and public life science and technology companies. Moore received his Bachelors of Science degree from Cornell University and a Masters of Business Administration degree from Vanderbilt University.