A Novel Approach to Leveraging the Microbiome Organ

Mike Bonney is Executive Chair of Kaleido's Board of Directors, and served as CEO from June 2017 until August 2018. Previously, Bonney was CEO and Director of Cubist Pharmaceuticals from 2003 until 2014. Under his leadership, Cubist grew from a struggling micro-cap to the world’s leading antibiotic company, and was acquired by Merck early in 2015 for $9.5 billion. Prior to Cubist, Bonney was Vice President of Sales and Marketing at Biogen where he built the company’s commercial infrastructure for the launch of its first product. Before joining Biogen, he spent 11 years at Zeneca Pharmaceuticals in a range of commercial, operating and strategic roles, ending his career there as National Business Director. Bonney also chairs the boards of Alnylam Pharmaceuticals, Magenta Therapeutics and Bates College. He is a member of a number of other boards, including Celgene Corporation, Sarepta Therapeutics, and Syros Therapeutics. Bonney was a regional winner and national finalist (2013) in the life science segment of Ernst & Young’s Entrepreneur of the Year and was one of six executives nationwide named as Marketwatch’s CEO of the Year (2011). He received his undergraduate degree in economics from Bates College.

Noubar Afeyan, Ph.D., is co-founder of Kaleido, and CEO of Flagship Pioneering, a leading early stage venture capital firm. He has been a senior lecturer at MIT’s Sloan School of Management where he has taught courses on technology-entrepreneurship, innovation, and leadership since 2000. Dr. Afeyan has authored numerous scientific publications and patents since earning his Ph.D. in biochemical engineering from MIT in 1987. He lectures widely in the United States and internationally on diverse topics ranging from entrepreneurship, innovation and venture capital to biological engineering, drug discovery, medical technologies and renewable energy. During his 28-year career as inventor, entrepreneur, CEO and venture capitalist, he has co-founded and helped build over 35 successful life science and technology startups. He was founder and CEO of PerSeptive Biosystems, a leader in the bio-instrumentation field that grew to over $100M in annual sales within six years from its first sales. After PerSeptive’s acquisition by Perkin Elmer/Applera Corporation in 1998, he was senior vice president and chief business officer of Applera, where he initiated and oversaw the creation of Celera Genomics. Currently Dr. Afeyan serves on a number of public and private company boards. Previously, he was a member of the founding team, director and investor in several highly successful ventures including Chemgenics Pharmaceuticals (acquired by Millennium Pharmaceuticals), Color Kinetics (acquired by Philips), Adnexus Therapeutics (acquired by Bristol-Myers Squibb) and Affinnova (acquired by AC Nielsen). Dr. Afeyan is a member of the corporation (board of trustees) of MIT and a member of the board of overseers of the Boston Symphony Orchestra. He also serves on the boards of the Armenian General Benevolent Union, the IDeA Foundation and the UWC Dilijan International School. Dr. Afeyan is engaged in a number of philanthropic initiatives. In 2015, he co-founded the 100 LIVES Initiative, which commemorated the 100th anniversary of the start of the Armenian genocide and created a remembrance project to locate and preserve stories of both survivors and rescuers from the genocide.

Bonnie Bassler, Ph.D., is Chair of the Department of Molecular Biology and the Squibb Professor of Molecular Biology at Princeton University, and a Howard Hughes Medical Institute Investigator. She previously served as the President of the American Society for Microbiology, and on the Boards of the American Association for the Advancement of Science, the National Science Foundation and also chaired the Board of the American Academy of Microbiology. Dr. Bassler has been elected to the National Academy of Sciences, the American Academy of Arts and Sciences, the Royal Society and the American Philosophical Society. She is the recipient of the MacArthur Foundation Fellowship, the Lounsbery Award and the Shaw Prize for Life Science and Medicine. Dr. Bassler received her B.S. from the University of California, Davis, and her Ph.D. in Biochemistry from Johns Hopkins University.

Mr. Burnett is Co-Founder and General Partner at Bow Capital, an early stage venture capital firm he started in July 2016. Previously, he served as Chief Operating Officer of Flurry, Inc., a mobile analytics, monetization and advertising company. Mr. Burnett previously served as Vice President, Global Sales and Operations at Facebook, Inc., Director, North American Sales and Operations for Google, and Vice President, North American Sales, at DoubleClick. He serves on the Boards of East Palo Alto Tennis and Tutoring and Menlo School. Mr. Burnett is a graduate of the University of Michigan and received his M.B.A. from Harvard Business School.

Alison Lawton has served as Kaleido’s Chief Executive Officer, President and as a member of the Board of Directors since August 2018, after initially joining the company as President and Chief Operating Officer in December 2017. Ms. Lawton has more than 30 years of experience in a range of executive and operating roles in the biopharmaceutical industry. Prior to joining Kaleido, she was COO at Aura Biosciences, and previously held the same role at X4 Pharmaceuticals and OvaScience. Ms. Lawton spent more than 20 years at Genzyme Corporation and subsequently at Sanofi following its acquisition of Genzyme. She served as Senior Vice President and General Manager of Sanofi Biosurgery, a $750 million business that included surgical, orthopedics, and cell therapy and regenerative medicine franchises. Earlier, as SVP of Global Market Access for Genzyme, Ms. Lawton led global functional organizations, including regulatory affairs and quality systems, public policy, health outcomes and strategic pricing, product safety and risk management. Additionally, Ms. Lawton worked for seven years in the U.K. at Warner-Lambert/Parke-Davis. She previously served two terms as the industry representative on the Food & Drug Administration’s Cell & Gene Therapy Advisory Committee and as Chairman of the Board of the Regulatory Affairs Professional Society (RAPS). She is currently an independent Director of ProQR Therapeutics and Verastem, Inc., and was previously a director on the boards of Cubist Pharmaceuticals, CoLucid Pharmaceuticals, and Magenta Therapeutics. Ms. Lawton earned her Bachelor of Science degree in Pharmacology from King’s College London.

Jonathan McIntyre, Ph.D., serves as Chief Executive Officer of Motif Ingredients. Previously, Dr. McIntyre was the Head of Research and Development at Indigo Agriculture, Inc. and served in various roles at PepsiCo, most recently as Senior Vice President, Research and Development. Earlier in his career, he was a science director at both E.I. du pont de Nemours and Company and Monsanto Company. Dr. McIntyre holds a B.S. in chemistry from Grove City College and a Ph.D. in biochemistry from the University of Cincinnati College of Medicine, where he also completed postdoctoral training.

Anthony G. Quinn, M.D., Ph.D., is President and Chief Executive Officer of Aeglea BioTherapeutics, Inc. Prior to that, he worked as a private consultant for IDBioPharm Consulting LLC. Previously, Dr. Quinn served as Executive Vice President, Head of Research & Development and Chief Medical Officer for Synageva BioPharma Corp., which was acquired by Alexion Pharmaceuticals, Inc. in June 2015. Dr. Quinn previously served as worldwide Head of Clinical Research and Exploratory Development for inflammatory diseases at Roche. Dr. Quinn received his BMSc. in general pathology and his MB ChB (M.D.) from the University of Dundee, UK. and his Ph.D. in cancer research from the University of Newcastle in Tyne, UK. He completed a postdoctoral fellowship at University of California, San Francisco before being appointed Professor of Dermatology at Barts & The London School of Medicine, UK. Dr. Quinn is a fellow of the Royal College of Physicians London.

JMr. Sculley is Vice Chairman for Celularity, Inc., a placenta cord blood stem cell company, Chairman of the Board of Directors and Chief Marketing Officer for RxAdvance Corporation, a modern Pharmacy Benefit Manager platform company. He is also the Co-founder and Vice Chairman of Zeta Global, a personalized marketing platform. Mr. Sculley was previously Chief Executive Officer of Pepsi-Cola Co. and the Chief Executive Officer of Apple Inc. He was a founding Board member of MetroPCS Communications, Inc. and Rally Health, Inc. Mr. Sculley is a graduate of Brown University, earned a Wharton School M.B.A., holds 10 honorary Ph.D.s, and was awarded the Ellis Island Medal of Honor.

Geoffrey von Maltzahn, Ph.D., is a co-founder and Director of Kaleido, and has been a Partner at Flagship Pioneering since 2009. He has co-founded multiple other companies, including Seres Therapeutics, Indigo Agriculture, Axcella Health, and Sienna Biopharmaceuticals. Dr. von Maltzahn currently serves as Chief Innovation Officer for Indigo, where he led the creation of the world’s largest plant microbiome database and development of the company’s first commercial products. He is an inventor on more than 200 patents and patent applications in biotech, nutrition and microbiome-based technologies and has been recognized with numerous awards, including the prestigious Lemelson-MIT student prize, given to the most innovative student at MIT. Dr. von Maltzahn’s innovations have been profiled by the Economist, CNN, Fortune, Scientific American, Popular Science and others. Dr. von Maltzahn was awarded a Ph.D. in biomedical engineering and medical physics from MIT, a M.S. in bioengineering from the University of California, San Diego, and an S.B. in chemical engineering from MIT.

Dr. Glimcher is the President and CEO of the Dana-Farber Cancer Institute, Principal Investigator and Director of the Dana-Farber/Harvard Cancer Center, and the Richard and Susan Smith Professor of Medicine at Harvard Medical School. Previously, she was the Stephen and Suzanne Weiss Dean and Professor of Medicine of Weill Cornell Medicine, Provost for Medical Affairs of Cornell University, the Irene Heinz Given Professor of Immunology at the Harvard School of Public Health and Professor of Medicine at Harvard Medical School serving as Senior Physician and Rheumatologist at Brigham and Woman’s Hospital. Dr. Glimcher received her M.D. from Harvard Medical School.

Dr. Jenq is an Assistant Professor in the Department of Genomic Medicine and the Department of Stem Cell Transplantation, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center, Houston, TX. His laboratory examines the impact of the microbiome on cancer treatment, focusing in particular on bone marrow transplantation and cancer immunotherapies. Data from his group and others has demonstrated that the microbiome can be a potent modulator of cancer treatment efficacy and toxicity. Using a multidisciplinary approach, Professor Jenq hopes to develop and translate strategies to target the microbiome to further increase treatment efficacy while reducing toxicities. Dr. Jenq holds an M.D. from Oregon Health and Science University

Dr. Kahn is a world recognized expert in diabetes and obesity research, as well as a preeminent investigator in the area of insulin signal transduction and mechanisms of altered signaling in diabetes and metabolic disease. Dr. Kahn is Senior Investigator, Head of the Section on Integrative Physiology and Metabolism at Joslin Diabetes Center and the Mary K. Iacocca Professor of Medicine at Harvard Medical School. Dr. Kahn served as Research Director of the Joslin Diabetes Center from 1981 to 2000, and served as President of Joslin from 2001 to 2007. He is currently the Center’s Chief Academic Officer. He received his M.D. from the University of Louisville.

Dr. Kiessling is the Novartis Professor of Chemistry at the Massachusetts Institute of Technology (MIT) where her group focuses on using chemical biology to elucidate the biological roles of carbohydrates. She served as an American Cancer Society Postdoctoral Fellow at the California Institute Technology for two years before joining the faculty of the University of Wisconsin, Madison in 1991. She previously served as the Steenbock Professor of Chemistry, the Laurens Anderson Professor Biochemistry, and the Director of the Keck Center for Chemical Genomics. She holds a Ph.D. in chemistry from Yale University.

Dr. Nieuwdorp is a professor of Internal Medicine and endocrinologist at the University of Amsterdam’s Faculty of Medicine (AMC-UvA) and conducts research into the role of intestinal bacteria in the development of diabetes, fatty liver (steatosis) and cardiovascular disease. Through fecal transplants, Dr. Nieuwdorp investigates the causal role of intestinal bacteria that are involved in the emergence of these diseases and potential treatments. In addition to directing the Academic Medical Center’s diabetes unit and laboratory for Experimental Vascular Medicine, Dr. Nieuwdorp also works as a diabetes researcher at the VU University Medical Center Amsterdam and serves as a visiting professor at the University of Gothenborg’s Wallenberg laboratory. He received his M.D. from Urecht University and his Ph.D. from the University of Amsterdam.

Dr. Turnbaugh is an Associate Professor in the Department of Microbiology and Immunology, the G.W. Hooper Research Foundation, and an Investigator in the Chan Zuckerberg Biohub, at the University of California, San Francisco. For over 15 years his research has focused on the metabolic activities performed by the trillion of microbes in the human body, using metagenomics and gnotobiotics to study the role of the gut microbiome in nutrition and pharmacology. He holds a Ph.D. in Microbial Genetics and Genomics from Washington University in St. Louis.